On September 7, 2017, in the season opener on Thursday Night Football against the defending Super Bowl champion New England Patriots, Hill finished with a career-high 133 receiving yards on seven receptions, which included a 75-yard reception for a touchdown, as the Chiefs won by a score of 42–27. In Week 5, against the Houston Texans, he recorded an 82-yard punt return touchdown in the fourth quarter. On October 30, against the Denver Broncos on Monday Night Football, Hill threw the first interception of the Chiefs’ season on a failed trick play. On November 5, against the Dallas Cowboys, he scored a 56-yard touchdown pass from Alex Smith on an unconventional end-of-half play. The Chiefs lined up like they were going to try a Hail Mary and Smith threw an underneath check-down pass to Hill who had a convoy of blockers clear enough space for him to maneuver to the end zone for the once-in-a-lifetime touchdown. During a Week 13 matchup against the New York Jets, Hill had 185 receiving yards on six receptions and two touchdowns, which included a 79-yard touchdown, but the Chiefs lost 31-38. On December 19, 2017, Hill was named to his second Pro Bowl as a return specialist. Overall, in the 2017 season, he finished with 75 receptions for 1,183 receiving yards and seven receiving touchdowns. In addition, he had 25 punt returns for 204 net yards and a return touchdown. The Chiefs finished the regular season with a 10–6 record and made the playoffs. In the 22–21 loss to the Tennessee Titans in the Wild Card Round, Hill finished with seven receptions for 87 yards and had a 14-yard rush.